The Seipke Lab

 

The Seipke Lab

 

The Seipke Lab

 

[View Google Scholar profile here and ORCID ID here]

 

2017

 

Som NF, Heine D, Holmes N, Knowles F, Chandra G, Seipke RF, Hoskisson PA, Wilkinson B, Hutchings MI. 2017. The MtrAB two component system controls antibiotic production in Streptomyces coelicolor A3(2). Microbiology, in press

 

Som NF, Heine D, Holmes NA, Munnoch JT, Chandra G, Seipke RF, Hoskisson PA, Wilkinson B, Hutchings MI. 2017. The conserved two-component system MtrAB coordinates chloramphenicol production with sporulation in Streptomyces venezuelae. Front Microbiol 8:1145. Full text Open Access

 

Zhiwei Q, Munnoch JT, Devine R, Holmes NA, Seipke RF, Wilkinson KA, Wilkinson B, Hutchings MI. 2017. Formicamycins, antibacterial polyketides produced by Streptomyces formicae isolated from African Tetraponera plant-ants. Chem Sci 8:3218-3227 Full text Open Access

 

2016

 

McLean TC, Hoskisson PA, Seipke RF. 2016. Coordinate regulation of antimycin and candicidin biosynthesis. mSphere 1(6):e00305-16. Full text Open Access

 

2015

 

Medema MH, Kottmann R, Yilmaz P, Cummings M, Biggins JB, Blin K, de Bruijn I, Chooi YH, Claesen J, Coates RC, Cruz-Morales P, Duddela S, Düsterhus S, Edwards DJ, Fewer DP, Garg N, Geiger C, Gomez-Escribano JP, Greule A, Hadjithomas M, Haines AS, Helfrich EJ, Hillwig ML, Ishida K, Jones AC, Jones CS, Jungmann K, Kegler C, Kim HU, Kötter P, Krug D, Masschelein J, Melnik AV, Mantovani SM, Monroe EA, Moore M, Moss N, Nützmann HW, Pan G, Pati A, Petras D, Reen FJ, Rosconi F, Rui Z, Tian Z, Tobias NJ, Tsunematsu Y, Wiemann P, Wyckoff E, Yan X, Yim G, Yu F, Xie Y, Aigle B, Apel AK, Balibar CJ, Balskus EP, Barona-Gómez F, Bechthold A, Bode HB, Borriss R, Brady SF, Brakhage AA, Caffrey P, Cheng YQ, Clardy J, Cox RJ, De Mot R, Donadio S, Donia MS, van der Donk WA, Dorrestein PC, Doyle S, Driessen AJ, Ehling-Schulz M, Entian KD, Fischbach MA, Gerwick L, Gerwick WH, Gross H, Gust B, Hertweck C, Höfte M, Jensen SE, Ju J, Katz L, Kaysser L, Klassen JL, Keller NP, Kormanec J, Kuipers OP, Kuzuyama T, Kyrpides NC, Kwon HJ, Lautru S, Lavigne R, Lee CY, Linquan B, Liu X, Liu W, Luzhetskyy A, Mahmud T, Mast Y, Méndez C, Metsä-Ketelä M, Micklefield J, Mitchell DA, Moore BS, Moreira LM, Müller R, Neilan BA, Nett M, Nielsen J, O'Gara F, Oikawa H, Osbourn A, Osburne MS, Ostash B, Payne SM, Pernodet JL, Petricek M, Piel J, Ploux O, Raaijmakers JM, Salas JA, Schmitt EK, Scott B, Seipke RF, Shen B, Sherman DH, Sivonen K, Smanski MJ, Sosio M, Stegmann E, Süssmuth RD, Tahlan K, Thomas CM, Tang Y, Truman AW, Viaud M, Walton JD, Walsh CT, Weber T, van Wezel GP, Wilkinson B, Willey JM, Wohlleben W, Wright GD, Ziemert N, Zhang C, Zotchev SB, Breitling R, Takano E, Glöckner FO. Minimum information about a biosynthetic gene cluster. Nat Chem Biol 11:625-631. Full text Open Access

 

Seipke RF. 2015. Strain-level diversity of secondary metabolism in Streptomyces albusPLoS One e0116457. Full text Open Access

 

Liu J, Zhu X, Seipke RF, Zhang W. 2015. Biosynthesis of antimycins with a reconstituted 3-formamidosalicylate pharmacophore in Escherichia coliACS Synth Biol 4:559-565. Abstract

 

2014

 

Gao H, Gruschow S, Barke J, Seipke RF, Hill LM, Orivel J, Yu DW, Hutchings MI, Goss RJM. 2014. Filipins: the first antifungal “weed killers” identified from bacteria isolated form the trap-ant. RSC Adv 4:57267-57270. Abstract

 

Seipke RF, Patrick E, Hutchings MI. 2014. Regulation of antimycin biosynthesis by the orphan RNA polymerase sigma factor σ AntA. PeerJ 2:e253. Full text Open Access

 

2013

 

Seipke RF, Hutchings MI. 2013. The regulation and biosynthesis of antimycins. Beilstein J Org Chem 19:2556-2563. Full text Open Access

 

Seipke RF, Barke J, Heavens D, Yu DW, Hutchings MI. 2013. Analysis of bacterial communities associated with two ant-plant symbioses. Microbiologyopen 2:276-283. Full text Open Access

 

Clark LC, Seipke RF, Prieto-Aranda P, Willemse J, van Wezel GP, Hutchings MI, Hoskisson PA. 2012. Mammalian cell entry genes in Streptomyces may provide clues to the evolution of bacterial virulence. Sci Rep 3:1109. Full text Open Access

 

2012

 

Seipke RF, Gruschow S, Goss RJM, Hutchings MI. 2012. Isolating antifungals from fungus-growing ant symbionts using a genome-guided chemistry approach. Methods Enzymol 517:47-70. Abstract

 

Moore JM, Bradshaw E, Seipke RF, Hutchings MI, McArthur M. Use and discovery of chemical elicitors that stimulate Streptomyces bacteria. Methods Enzymol 517:367-385. Abstract

 

Seipke RF, Kaltenpoth M, Hutchings MI. 2011. Streptomyces as symbionts: an emerging and widespread theme? FEMS Microbiol Rev 36:862-876. Abstract

 

2011

 

Seipke RF, Barke J, Brearley C, Hill L, Yu DW, Goss RG, Hutchings MI. 2011. A single Streptomyces mutualist makes multiple antifungals to support the fungus farming ant Acromyrmex octospinosusPLoS One 6:e22028. Full text Open Access

 

Seipke RF, Song L, Bicz J, Laskaris P, Yaxley AM, Challis GL, Loria R. 2011. The plant pathogen Streptomyces scabies 87-22 has a functional pyochelin biosynthetic pathway that is regulated by TetR- and AfsR-family protein. Microbiology 157:2681-2693. Abstract Open Access

 

Seipke RF, Barke J, Ruiz-Gonzalez MX, Orivel J, Yu DW, Hutchings MI. 2011. Fungus-growing Allomerus ants are associated with antibiotic-producing actinobacteria. Antonie van Leeuwenhoek 101:443-447. Abstract

 

Seipke RF, Crossman LC, Drou N, Heavens D, Bibb MJ, Caccamo M, Hutchings MI. 2011. Draft Genome Sequence of Streptomyces S4, a symbiont of the leaf-cutting ant Acromyrmex octospinosusJ Bacteriol 193:4270-4271. Abstract

 

Barke J, Seipke RF, Yu DW, Hutchings MI. 2011. A mutualistic microbiome: how do fungus-growing ants select their antibiotic-producing bacteria? Commun Integr Biol 4:41-43. Full text Open Access

 

2010

 

Barke J, Seipke RF, Grüschow S, Heavens D, Drou N, Bibb MJ, Goss RJ, Yu DW, Hutchings MI. 2010. A mixed community of actinomycetes produce multiple antibiotics for the fungus farming ant Acromyrmex octospinosusBMC Biol 8:109. Full text Open Access

 

Bignell DR, Seipke RF, Huguet-Tapia JC, Chambers AH, Parry RJ, Loria R. 2010. Streptomyces scabies 87-22 contains a coronafacic acid-like biosynthetic cluster that contributes to plant-microbe interactions. Molecular Plant-Microbe Interactions 23:161-175. Abstract

 

2009

 

Seipke RF, Loria, R. 2009. Hopanoids are not essential for growth of Streptomyces scabies 87-22. J Bacteriol 191:5216-5223. Abstract

 

2008

 

Seipke RF, Loria R. 2008. Streptomyces scabies 87-22 possesses a functional tomatinase. J Bacteriol 190:7684-7692. Abstract

 

Loria R, Bignell DR, Moll S, Huguet-Tapia JC, Joshi MV, Johnson EG, Seipke RF, Gibson DM. 2008. Thaxtomin biosynthesis: The path to plant pathogenicity in the genus StreptomycesAntonie Van Leeuwenhoek 94:3-10. Abstract

 

 

 

University of Leeds | School of Molecular & Cellular Biology | (e): r.seipke (at) leeds.ac.uk | (t): +44(0) 113 34 35604

 

 

 

 

 

© Copyright Ryan F. Seipke